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Some interfere with natural insulin production, while others activate biological pathways that healthy cells use for growth and repair

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3 RGN-259 Phase 3 Trial in Neurotrophic Keratopathy Sosne et al., International Journal of Molecular Sciences (2022) This Phase 3 randomized, placebo-controlled, double-masked clinical trial evaluated topical 0.1% RGN-259 (full-length recombinant T4 ophthalmic solution) in patients with neurotrophic keratopathy

BPC-157 administration in rat models of mesenteric artery ligation has been shown to restore NO bioavailability in ischemic tissue beds within timeframes as short as 30 minutes post-administration, an effect blocked by pre-treatment with L-NAME (a non-selective NOS inhibitor), confirming the NO-dependent mechanism